Make sure that at least one of the holes is of sufficient size for the jigsaw blade. Cut the slot from one hole to the other along the lines you’ve marked, being sure to stay within the lines you’ve drawn. That would make it a little easier to hold the piece, at least till you get close to the end.
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How to Cut Slots in Wood 9 Steps (with Pictures) wikiHow
Mark where the slot will go, and drill two holes, one at each end of the intended slot.